Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BMS-955829
Catalog No.: PC-61070Not For Human Use, Lab Use Only.
A potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM); displays no any measurable PAM, NAM or agonist activity at other mGluRs (>10 uM); reverses MK-801 induced deficits in executive function in rats, demonstrates robust in vivo efficacy in preclinical models of schizophrenia.
| M.Wt | 376.363 | |
| Formula | C22H14F2N2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Yang F, et al. ACS Med Chem Lett. 2016 Jan 4;7(3):289-93.
2. Narang AS, et al. Eur J Pharm Biopharm. 2017 Aug;117:333-345.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
