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You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Diglyceride Acyltransferase (DGAT)-BMS-963272
BMS-963272

Chemical Structure : BMS-963272

CAS No.: 1441057-15-3

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BMS-963272 (BMS 963272)

Catalog No.: PC-73223Not For Human Use, Lab Use Only.

BMS-963272 is a potent, selective MGAT2 inhibitor with IC50 of 7.1 and 18 nM for human and mouse MAGT2, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-963272 is a potent, selective MGAT2 inhibitor with IC50 of 7.1 and 18 nM for human and mouse MAGT2, respectively.
BMS-963272 decreaseed inflammation and fibrosis in CDAHFD and STAM, two murine nonalcoholic steatohepatitis (NASH) models.
BMS-963272 did not cause diarrhea in high-fat-diet-treated cynomolgus monkeys, in contrast to a selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor.

Physicochemical Properties

M.Wt 525.45
Formula C24H21F6N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2(1H)-Pyridinone, 5,6-dihydro-4-(4-methylphenyl)-3-(2H-tetrazol-5-yl)-6-[4-(4,4,4-trifluorobutoxy)phenyl]-6-(trifluoromethyl)-, (6S)-

References

1. Cheng D, et al. Cell Metab. 2022 Nov 1;34(11):1732-1748.e5.

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