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Chemical Structure : BMS-986120
Catalog No.: PC-60548Not For Human Use, Lab Use Only.
BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
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BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
BMS-986120 selectivity inhibits PAR4 AP-induced cellular calcium mobilization in HEK cells with IC5o of 0.56 nM, with no activity on PAR1 and PAR2.
BMS-986120 inhibits human PRP aggregation in response to γ-thrombin in vitro with IC50 of 7.3 nM.
BMS-986120 demonstrates potent and highly efficacious antithrombotic activity with low bleeding in vivo.
| M.Wt | 513.587 | |
| Formula | C23H23N5O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wong PC, et al. Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294.
2. Moschonas IC, et al. Platelets. 2017 Dec;28(8):812-821.
3. Wilson SJ, et al. Arterioscler Thromb Vasc Biol. 2017 Dec 21. pii: ATVBAHA.117.310104.
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