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Chemical Structure : BMS-986172
Catalog No.: PC-21221Not For Human Use, Lab Use Only.
BMS-986172 is a highly potent, selective monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with IC50 of 4.6 nM (human MGAT2).
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BMS-986172 is a highly potent, selective monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with IC50 of 4.6 nM (human MGAT2).
BMS-986172 shows no activity against lipid acyltransferases including recombinant human DGAT1, DGAT2, MGAT1, AWAT1, AWAT2, DC3, ACAT1, and ACAT2 (all IC50 > 30 uM), MGAT3 (IC50=16 uM).
BMS-986172 shows excellent liver microsome and UGT metabolic stabilities, and no species-variable glucuronidation.
BMS-986172 (0.03, 0.1, 0.3, and 1.0 mg/kg) displays a statistically significant and dose-dependent reduction in food intake in DIO mice, reduces food intake and body weight in wild-type mice with a minimum efficacious dose of 0.1 mg/kg (5% weight loss).
| M.Wt | 589.47 | |
| Formula | C24H22F7N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wei Meng, et al. J Med Chem. 2023 Sep 19. doi: 10.1021/acs.jmedchem.3c01147.
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