Chemical Structure : BMS-986331
CAS No.:
2375684-52-7
BMS-986331
(BMS986331)
Catalog No.: PC-26270Not For Human Use, Lab Use Only.
BMS-986331 is a highly potent and selective Formyl peptide receptor 2 (FPR2) agonist with EC50 of 0.5 nM (hFPR2).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BMS-986331 is a highly potent and selective Formyl peptide receptor 2 (FPR2) agonist with EC50 of 0.5 nM (hFPR2).
BMS-986331 exhibits rat FPR2 cAMP EC50 of 1 nM, 220-fold selective over rFPR1.
BMS-986331 induces concentration-dependent modulation of bioluminescence resonance energy transfer (BRET) signals for Gαi2 (EC50=0.5 nM), GαoA (EC50=0.5 nM), Gα12 (EC50=16 nM), and Gα13 (EC50=13 nM) biosensors following FPR2 activation in in HEK293 cells transiently expressing human FPR2.
BMS-986331 exhibits excellent activity in inducing the expression and release of the pro-resolution cytokine IL-10 in isolated human whole blood and in an acute rat model of systemic inflammation, respectively.
BMS-986331 (0.1, 1, or 10 mg/kg/day, PEG 400/PG/TPGS/water, 40:10:10:40) preserves myocardial structure and improves cardiac function in the rat MI model.
Physicochemical Properties
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M.Wt
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535.89
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Formula
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C25H22ClF3N3O3P
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-1-(4-Chloro-2-fluorophenyl)-3-(1-(2′-(dimethylphosphoryl)-2,3-difluoro-[1,1′-biphenyl]-4-yl)-2-oxopyrrolidin-3-yl)urea
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References
1. Shirude PS, et al. J Med Chem. 2026 Feb 26;69(4):4078-4089.
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