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Chemical Structure : BMT-145027
Catalog No.: PC-61069Not For Human Use, Lab Use Only.
A potent, selective, non-MPEP site mGluR5 positive allosteric modulator with EC50 of 47 nM, without inherent mGluR5 agonist activity (EC50>16 uM).
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A potent, selective, non-MPEP site mGluR5 positive allosteric modulator with EC50 of 47 nM, without inherent mGluR5 agonist activity (EC50>16 uM); does not engage the receptor at the MPEP and CPPHA allosteric sites, improves cognition in a preclinical rodent model of learning and memory.
| M.Wt | 438.838 | |
| Formula | C23H14ClF3N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hill MD, et al. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086.
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