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Chemical Structure : BNC-1
Catalog No.: PC-63196Not For Human Use, Lab Use Only.
BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2.
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BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2; increases levels of synaptophysin and synapsin, markers of synaptic integrity, but does not adversely impact presenilin-2 or processing of Notch-1, significantly decreases amyloid burden and improves markers of synaptic integrity in a well-established mouse model of amyloid deposition.
| M.Wt | 282.299 | |
| Formula | C16H14N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lovell MA, et al. J Alzheimers Dis. 2016 May 4;53(1):273-87.
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