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Chemical Structure : BOS172722
CAS No.: 1578245-44-9
Catalog No.: PC-35662Not For Human Use, Lab Use Only.
BOS172722 (BOS-172722) is a potent, selective MPS1 kinase (TTK) inhibitor with biochemical IC50 of 11 nM, 100-fold selectivity over CDK2.
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|---|---|---|---|
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| 10 mg | $258 | In stock | |
| 50 mg | $658 | In stock | |
| 100 mg | $958 | In stock | |
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BOS172722 (BOS-172722) is a potent, selective MPS1 kinase (TTK) inhibitor with biochemical IC50 of 11 nM.
BOS172722 displays 100-fold selectivity over CDK2.
BOS172722 potently inhibits autophosphorylation of ectopically expressed MPS1 in HCT116 cells with IC50 of 63 nM.
BOS172722 demonstrates excellent selectivity against a wide panel of more than 400 kinases as well as a clean CYP and hERG profile.
BOS172722 exhibits robust efficacy in combination with paclitaxel in in vivo models.
| M.Wt | 446.559 | |
| Formula | C24H30N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine |
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1. Woodward HL, et al. J Med Chem. 2018 Sep 27;61(18):8226-8240.
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