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Chemical Structure : BPK-29
CAS No.: 2143467-62-1
Catalog No.: PC-60016Not For Human Use, Lab Use Only.
BPK-29 (BPK29) is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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BPK-29 (BPK29) is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
BPK-29 substantially engages NR0B1 (EC50<5 uM) with good overall proteomic selectivity in KEAP1-mutant NSCLCs.
BPK-29 target a conserved cysteine C274 within the NR0B1.
| M.Wt | 470.01 | |
| Formula | C26H32ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-benzyl-2-chloro-N-(1-(4-morpholinobenzoyl)azepan-4-yl)acetamide |
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1. Bar-Peled L, et al. Cell. 2017 Oct 19;171(3):696-709.e23.
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