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Chemical Structure : BPN15477
CAS No.: 1971086-99-3
Catalog No.: PC-49818Not For Human Use, Lab Use Only.
BPN-15477 (BPN15477) is a potent splicing modulator compound that restores correct splicing of ELP1 exon 20, increases full-length ELP1 mRNA by increasing exon 20 inclusion with EC50 of 1.9 uM in luciferase splicing assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $758 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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BPN-15477 (BPN15477) is a potent splicing modulator compound that restores correct splicing of ELP1 exon 20, increases full-length ELP1 mRNA by increasing exon 20 inclusion with EC50 of 1.9 uM in luciferase splicing assays.
BPN-15477 is significantly more potent and efficacious than kinetin, and BPN-15477 modulates splicing selectively.
BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain.
BPN-15477 treatment increases LIPA and CFTR protein in disease-relevant cellular models.
BPN-15477 treatment (70 mg/Kg/day) improves exon 20 inclusion in the retina and brain of mice carrying the human FD transgene TgFD9.
| M.Wt | 259.70 | |
| Formula | C12H10ClN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Chloro-N-(4-pyridinylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
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1. Dadi Gao, et al. Nat Commun. 2021 Jun 7;12(1):3332.
2. Salani, M. et al. SLAS Discov.24, 57–67 (2018).
3. Morini E, et al. J Genet Genomics. 2022 Jul;49(7):654-665.
4. Anil Chekuri, et al. Hum Mol Genet. 2022 Jun 4;31(11):1776-1787.
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