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Chemical Structure : BPO-27 racemate
CAS No.: 1314873-02-3
Catalog No.: PC-45712Not For Human Use, Lab Use Only.
BPO-27 is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
Bulk size, bulk discount!
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BPO-27 is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM); shows improved potency, metabolic stability, and aqueous solubility compared to PPQ-102; prevents cyst growth with IC50 of 100 nM in embryonic kidney culture model of PKD.
| M.Wt | 548.34162 | |
| Formula | C26H18BrN3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6 mg/mL |
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| Chemical Name/SMILES |
6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-, (6R)- |
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1. Snyder DS, et al. J Med Chem. 2011 Aug 11;54(15):5468-77.
2. Snyder DS, et al. ACS Med Chem Lett. 2013 May 9;4(5):456-459.
3. Kim Y, et al. Mol Pharmacol. 2015 Oct;88(4):689-96.
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