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Chemical Structure : BPRCX714
Catalog No.: PC-49201Not For Human Use, Lab Use Only.
BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM.
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BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM.
BPRCX714 exhibits no cross-activity against a panel of chemokine receptors in both CCR and CXCR types.
BPRCX714 is a promising drug candidate for PBSCT and other disease indications, can mobilize out neutrophils, lymphocytes and monocytes.
| M.Wt | 613.812 | |
| Formula | C30H51N11O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chien-Huang Wu, et al. J Med Chem. 2018 Feb 8;61(3):818-833.
2. Jen-Shin Song, et al. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2015433118.
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