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Chemical Structure : BPTES
CAS No.: 314045-39-1
Catalog No.: PC-43147Not For Human Use, Lab Use Only.
BPTES is a potent, selective kidney-type glutaminase 1 (GLS1) inhibitor with Ki of 3 uM (rat KGA), selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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BPTES is a potent, selective kidney-type glutaminase 1 (GLS1) inhibitor with Ki of 3 uM (rat KGA), selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase.
BPTES inhibits the allosteric activation caused by phosphate binding and promotes the formation of an inactive complex.
BPTES slows growth of glioblastoma cells expressing mutant IDH1 compared with those expressing wild-type IDH1, lowers glutamate and α-KG levels, and increases glycolytic intermediates while leaving total 2-HG levels unaffected.
BPTES nanoparticles significantly reduces pancreatic tumor combined with metformin in vivo.
| M.Wt | 524.6813 | |
| Formula | C24H24N6O2S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 41 mg/mL |
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| Chemical Name/SMILES |
Benzeneacetamide, N,N'-[thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bis- |
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1. Robinson MM, et al. Biochem J. 2007 Sep 15;406(3):407-14.
2. Seltzer MJ, et al. Cancer Res. 2010 Nov 15;70(22):8981-7.
3. Elgogary A, et al. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5328-36.
4. Shukla K, et al. J Med Chem. 2012 Dec 13;55(23):10551-63.
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