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BQR-695

Chemical Structure : BQR-695

CAS No.: 1513879-21-4

BQR-695 (BQR695;NVP-BQR695)

Catalog No.: PC-61695Not For Human Use, Lab Use Only.

BQR-695 (NVP-BQR695) is a highly potent, selective PI4KIIIβ inhibitor that has high potency against both the human (IC50 = 80 nM) and PvPI4K (IC50=3.5 nM) .

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BQR-695 (NVP-BQR695) is a highly potent, selective PI4KIIIβ inhibitor that has high potency against both the human (IC50 = 80 nM) and PvPI4K (IC50=3.5 nM) ; shows >100 fold more potent over all other class I and class III PI3K isoforms; induces a schizont-stage arrest in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines; a novel antimalarial compound that inhibits the intracellular development of multiple Plasmodium species at each stage of infection in the vertebrate host.

Physicochemical Properties

M.Wt 352.394
Formula C19H20N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide

References

1. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.

2. Fowler ML, et al. Protein Sci. 2016 Apr;25(4):826-39.

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