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Chemical Structure : BQU57
CAS No.: 1637739-82-2
Catalog No.: PC-43278Not For Human Use, Lab Use Only.
BQU57 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 2.0 and 1.3 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $278 | In stock | |
| 100 mg | Get quote |
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BQU57 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 2.0 and 1.3 uM, respectively.
BQU57 acts specifically through the GDP-bound form of Ral proteins, RalAG23V or RalBG23V, mitigates inhibition of H2122 and H358 cell growth.
BQU57 shows selectivity for Ral relative to Ras or Rho and inhibits xenograft tumor growth similar to depletion of Ral by siRNA.
| M.Wt | 334.2958 | |
| Formula | C16H13F3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]- |
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1. Yan C, et al. Nature. 2014 Nov 20;515(7527):443-7.
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