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Chemical Structure : BRD-K98645985
CAS No.: 1357647-78-9
Catalog No.: PC-38594Not For Human Use, Lab Use Only.
BRD-K98645985 is a small molecule inhibitor of BAF (mammalian SWI/SNF)-mediated transcription with EC5 of 2.37 uM, binds ARID1A-specific BAF complexes, reverses HIV-1 latency in vitro and ex vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $598 | In stock | |
| 5 mg | $988 | In stock |
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BRD-K98645985 is a small molecule inhibitor of BAF (mammalian SWI/SNF)-mediated transcription with EC5 of 2.37 uM, binds ARID1A-specific BAF complexes, reverses HIV-1 latency in vitro and ex vivo.
Among the alternate epigenetic targets being investigated for reversing HIV-1 latency, one potential candidate is the mammalian SWI/SNF chromatin remodeling complex, BAF, which has been shown to contribute to HIV-1 transcriptional repression.
BAF complexes are multisubunit ATP-dependent chromatin remodelers known for their roles in development and cancer.
| M.Wt | 573.73 | |
| Formula | C33H43N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(1-Methylethyl)-N′-[(3S,6S,7R)-3,4,5,6,7,8,9,10-octahydro-7-methoxy-3,6,9-trimethyl-10-oxo-4-[[4-(2-pyridinyl)phenyl]methyl]-2H-1,4,9-benzoxadiazacyclododecin-12-yl]urea |
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1. Marian CA, et al. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.
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