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Chemical Structure : BRD5631
Catalog No.: PC-70317Not For Human Use, Lab Use Only.
BRD5631 is a small-molecule enhancer of autophagy through an mTOR-independent pathway.
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BRD5631 is a small-molecule enhancer of autophagy through an mTOR-independent pathway.
BRD5631 significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs.
BRD5631 significantly reduces levels of endogenous p62 and cell death in NPC1 hiPSC-derived neurons.
BRD5631 enhances bacterial clearance and suppresses IL-1β Secretion in an autophagy-dependent manner.
BRD5631 is a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease.
| M.Wt | 501.627 | |
| Formula | C30H35N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kuo SY, et al. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7.
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