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Chemical Structure : BRD6688
CAS No.: 1404562-17-9
Catalog No.: PC-72673Not For Human Use, Lab Use Only.
BRD6688 is a potent, kinetically selective HDAC2 inhibitor with IC50 of 21/100 nM for HDAC1/2, >115-fold selectivity versus HDAC3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | $1180 | In stock | |
| 1 g | Get quote |
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BRD6688 is a potent, kinetically selective HDAC2 inhibitor with IC50 of 21/100 nM for HDAC1/2, >115-fold selectivity versus HDAC3.
BRD6688 produced significant increases in AcH4K12 and AcH3K9 in mouse forebrain primary neuronal cultures.
BRD6688 rescued the memory defects associated with p25 induced neurodegeneration in CK-p25 induced neurodegenerative model.
| M.Wt | 282.3 | |
| Formula | C16H18N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[2-amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide |
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1. F F Wagner, et al. Chem Sci. 2015 Jan 1;6(1):804-815.
2. Wagner FF, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4008-4015.
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