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Chemical Structure : BRD6989
CAS No.: 642008-81-9
Catalog No.: PC-60893Not For Human Use, Lab Use Only.
BRD6989 is a potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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BRD6989 is a potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex.
BRD6989 displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM).
BRD6989 inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM.
| M.Wt | 264.332 | |
| Formula | C16H16N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile |
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1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108.
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