Chemical Structure : BRD9500
CAS No.: 1630760-75-6
Catalog No.: PC-25668Not For Human Use, Lab Use Only.
BRD9500 is a potent, selective and orally active phosphodiesterases 3 (PDE3) inhibitor with IC50 of 10 and 27 nM for PDE3A and PDE3B, respectively.
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BRD9500 is a potent, selective and orally active phosphodiesterases 3 (PDE3) inhibitor with IC50 of 10 and 27 nM for PDE3A and PDE3B, respectively.
BRD9500 is potent against biomarker-positive HeLa and SK-MEL-3 cells, selective for PDE3 in a PDE panel, clean in a CYP panel, hERG assay, and Ames test, and active in a murine model of melanoma.
| M.Wt | 291.33 | |
| Formula | C15H18FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-6-(3-fluoro-4-morpholinophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one |
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1. Lewis TA, et al. ACS Med Chem Lett. 2024 Sep 10;15(10):1662-1667.
2. Lewis T. A. et al. ACS Med. Chem. Lett. 2019, 10, 1537–1542.

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