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Chemical Structure : BRL-50481
CAS No.: 433695-36-4
Catalog No.: PC-61339Not For Human Use, Lab Use Only.
BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5.
BRL-50481 inhibits TNFalpha generation, demonstrates pharmacological activity on proinflammatory responses in human blood monocytes, lung macrophages, and CD8+ T-lymphocytes.
BRL-50481 induces anxiolytic and anorexigenic like behavior in rats.
| M.Wt | 244.267 | |
| Formula | C9H12N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N,N,2-Trimethyl-5-nitrobenzenesulfonamide |
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1. Smith SJ, et al. Mol Pharmacol. 2004 Dec;66(6):1679-89.
2. Pekkinen M, et al. Bone. 2008 Jul;43(1):84-91.
3. Valdés-Moreno MI, et al. Behav Brain Res. 2017 Feb 15;319:165-173.
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