Catalog No.: PC-22472Not For Human Use, Lab Use Only.
BTZ043 (BTZ-043) is a small molecule antimycobacterial agent taregting the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase, shows MIC values of 1 ng/ml (2.3 nM) and 4 ng/ml (9.2 nM) against M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
BTZ043 (BTZ-043) is a small molecule antimycobacterial agent taregting the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase, shows MIC values of 1 ng/ml (2.3 nM) and 4 ng/ml (9.2 nM) against M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
BTZ043 abolishes the formation of decaprenylphosphoryl arabinose, a key precursor that is required for the synthesis of the cell-wall arabinans, thus provoking cell lysis and bacterial death.
