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BVL-GSK098

Chemical Structure : BVL-GSK098

CAS No.: 2285440-39-1

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BVL-GSK098 (Alpibectir, BVL-GSK 098)

Catalog No.: PC-49179Not For Human Use, Lab Use Only.

BVL-GSK098 (Alpibectir) is a small molecule able to inhibit Mycobacterium tuberculosis transcription regulator VirS, boosts bioactivation of ethionamide (ETH) and lower ETH MIC.

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10 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BVL-GSK098 (Alpibectir) is a small molecule able to inhibit Mycobacterium tuberculosis transcription regulator VirS, boosts bioactivation of ethionamide (ETH) and lower ETH MIC.
BVL-GSK098 (Alpibectir) activates an EthA-independent-, VirS-dependent bioactivation pathway of ETH, makes ETH-resistant Mtb again susceptible to low ETH concentrations.

Physicochemical Properties

M.Wt 332.246
Formula C12H14F6N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4,4-trifluoro-1-(3-(trifluoromethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one

References

1. Patent WO2019034700 A1 2019-02-21.

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