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Chemical Structure : BX-320
Catalog No.: PC-63030Not For Human Use, Lab Use Only.
BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM, >20-fold selectivity over PKA.
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BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM, >20-fold selectivity over PKA; blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis; inhibits the growth of LOX melanoma tumors in the lungs of nude mice.
| M.Wt | 547.458 | |
| Formula | C23H31BrN8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.
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