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Chemical Structure : BX471
CAS No.: 217645-70-0
Catalog No.: PC-42889Not For Human Use, Lab Use Only.
BX471 is a potent, selective, non-peptide CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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BX471 is a potent, selective, non-peptide CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1.
BX471 shows 10,000-fold selectivity for CCR1 compared with 28 GPCRs.
BX471 displays CCR1 ligands MIP-1α, RANTES, and MCP-3 with high affinity (Ki=1-5.5 nM), inhibits a number of CCR1-mediated effects including Ca(2+) mobilization, increase in extracellular acidification rate, CD11b expression.
BX471 effectively reduces disease in a rat experimental allergic encephalomyelitis model of multiple sclerosis.
| M.Wt | 434.8917 | |
| Formula | C21H24ClFN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 51 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- |
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1. Horuk R, et al. J Biol Chem. 2001 Feb 9;276(6):4199-204.
2. Anders HJ, et al. J Clin Invest. 2002 Jan;109(2):251-9.
3. Strasly M, et al. Blood. 2004 Jan 1;103(1):40-9.
4. Liang M, et al. J Biol Chem. 2000 Jun 23;275(25):19000-8.
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