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Chemical Structure : BXI-72
CAS No.: 23491-52-3
Catalog No.: PC-35590Not For Human Use, Lab Use Only.
BXI-72 (NSC334072, Hoechst 33342) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 100 mg | $188 | In stock | |
| 500 mg | $468 | In stock | |
| 1 g | Get quote |
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BXI-72 (NSC334072, Hoechst 33342) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM).
BXI-72 displays very low binding affinities with Bcl2 (Ki=283 nM), Mcl-1, Bcl-w and Bfl-1/A1 (Ki>1500 nM).
BXI-72 potently suppresses lung cancer cell growth (H1299=0.49 uM, A549 IC50=0.68 uM), displays relatively selective cytotoxicity against lung cancer cells compared to normal human bronchial epithelial cells.
BXI-72 causes disruption of Bcl-XL/Bak or Bcl-XL/Bax interaction, oligomerization of Bak, and cytochrome c release from mitochondria in cells.
BXI-72 exhibits more potent efficacy against human lung cancer than ABT-737 but less degree in platelet reduction in vivo.
BXI-72 (NSC334072, Hoechst 33342) is a marker dye in Hoechst series for live nuclear marker dye.
| M.Wt | 489.01 | |
| Formula | C27H29ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole |
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1. Park D, et al. Cancer Res. 2013 Sep 1;73(17):5485-96.
2. Barrott JJ, et al. Mol Cancer Res. 2017 Dec;15(12):1733-1740.
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