Chemical Structure : Bacterial SPase inhibitor MD3
CAS No.:
491608-59-4
Bacterial SPase inhibitor MD3
Catalog No.: PC-25079Not For Human Use, Lab Use Only.
Bacterial SPase inhibitor MD3 a small molecule inhibitor of bacterial type I signal peptidases (SPases) with IC50 of 10 uM against P. aeruginosa LepB protein.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Bacterial SPase inhibitor MD3 a small molecule inhibitor of bacterial type I signal peptidases (SPases) with IC50 of 10 uM against P. aeruginosa LepB protein.
MD3 inhibits recombinant Escherichia coli SPase (LepB).
MD3 demonstrates potent activity against wild-type and multidrug-resistant strains of A. baumannii and S. maltophilia with MICs ranging from 0.5 to 14 mg/L in the presence of subinhibitory concentrations of colistin.
Physicochemical Properties
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M.Wt
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246.13
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Formula
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C11H13Cl2NO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one
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References
1. Personne Y, et al. J Antimicrob Chemother. 2014 Dec;69(12):3236-43.
2. Ollinger J, et al. J Bacteriol. 2012 May;194(10):2614-9.
3. Barbosa MD, et al. Antimicrob Agents Chemother. 2002 Nov;46(11):3549-54.
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