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Chemical Structure : Bax activator compound 106
CAS No.: 1638526-94-9
Catalog No.: PC-60922Not For Human Use, Lab Use Only.
Bax activator compound 106 (ZINC14750348) is a specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $328 | In stock | |
| 5 mg | $548 | In stock | |
| 10 mg | $898 | In stock | |
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| 100 mg | Get quote |
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Bax activator compound 106 (ZINC14750348) is a specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis.
Bax activator compound 106 alters Bax protein stability in vitro and promotes the insertion of Bax into mitochondria, leading to Bax-dependent permeabilization of the mitochondrial outer membrane.
Bax activator compound 106 induces significant cell death and caspase 3/7 activation in Bax-expressing cells, inhibits the growth of transplanted tumors as a single agent.
| M.Wt | 488.632 | |
| Formula | C29H36N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[(3,4-dimethylphenyl)methyl]-1-[(3-methoxyphenyl)methyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-ium-3-yl}-[(3R)-3-hydroxypiperidin-1-yl]methanone |
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1. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023.
2. Zhao G, et al. Mol Cell Biol. 2014 Apr;34(7):1198-207.
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