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Chemical Structure : Bcl3 inhibitor JS6
Catalog No.: PC-38199Not For Human Use, Lab Use Only.
Bcl3 inhibitor JS6 is a novel potent, antimetastatic Bcl3 inhibitor, targeting the Bcl3-p50 interaction site.
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Bcl3 inhibitor JS6 is a novel potent, antimetastatic Bcl3 inhibitor, targeting the Bcl3-p50 interaction site.
Bcl3 inhibitor JS6 suppresses NF-kB signaling in NF-kB luciferase reporter assay and inhibits multimodal migration of breast cancer cells with IC50 of 310 nM.
JS6 treatment led to reductions in Bcl3-NF-kB1 binding, tumor colony formation, and cancer cell migration in vitro. JS6 inhibited tumor stasis and showed antimetastatic activity in vivo, while being devoid of overt systemic toxicity.
| M.Wt | 371.412 | |
| Formula | C20H22FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jitka Soukupová, et al. Mol Cancer Ther. 2021 May;20(5):775-786.
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