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Belimumab

Chemical Structure : Belimumab

CAS No.:

Belimumab (Anti-human BAFF mAb, human IgG1 E239D,M241L-human lambda3 K83R)

Catalog No.: PC-Ab1086Not For Human Use, Lab Use Only.

Belimumab is a human IgG1λ monoclonal antibody that targets soluble human B lymphocyte stimulator proteins (BLyS, or BAFF and TNFSF13B). BLyS is unable to bind to receptors on B lymphocytes. The binding of BLyS to its receptor is essential for the survival of B lymphocytes. Consequently, belimumab reduces B-cell mediated immunity and the autoimmune response..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Belimumab is a human IgG1λ monoclonal antibody that targets soluble human B lymphocyte stimulator proteins (BLyS, or BAFF and TNFSF13B). BLyS is unable to bind to receptors on B lymphocytes. The binding of BLyS to its receptor is essential for the survival of B lymphocytes. Consequently, belimumab reduces B-cell mediated immunity and the autoimmune response.

Physicochemical Properties

M.Wt
Formula Human IgG1 E239D, M241L-Human lambda3 K83R
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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