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Bimoclomol

Chemical Structure : Bimoclomol

CAS No.: 130493-03-7

Bimoclomol (BRLP-42;BRLP 42;BRLP42)

Catalog No.: PC-60546Not For Human Use, Lab Use Only.

A potent heat shock protein coinducer.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent heat shock protein coinducer; increases an inducible member of the heat shock protein 70 family (HSP70) and cytoprotect in vitro, reduces infarct size in a rat model of ischemia and reperfusion; facilitates the formation of chaperone molecules in eukaryotic cells by inducing or amplifying expression of heat-shock genes.

Physicochemical Properties

M.Wt 297.783
Formula C14H20ClN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-hydroxy-3-(1-piperidinyl) propoxy]-3-pyridinecarboximidoil-chloride

References

1. Vígh L, et al. Nat Med. 1997 Oct;3(10):1150-4.

2. Erdö F, et al. Brain Res Bull. 1998;45(2):163-6.

3. Nánási PP, et al. Br J Pharmacol. 2000 Apr;129(7):1405-12.

4. Lubbers NL, et al. Eur J Pharmacol. 2002 Jan 18;435(1):79-83.

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