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Bindarit

Chemical Structure : Bindarit

CAS No.: 130641-38-2

Bindarit (AF2838)

Catalog No.: PC-20616Not For Human Use, Lab Use Only.

Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity.
Bindarit displays no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23, RANTES/CCL5, and IL8/CXCL8.
Bindarit dose-dependently inhibits MCP-1 and TNF-alpha production induced in vitro in monocytes by LPS and Candida albicans, does not affect the production of the cytokines IL-1, IL-6, or the chemokines IL-8, MIP-1alpha and RANTES.
Bindarit reduces monocyte recruitment and local MCP-1 production, induced by carrageenan or IL-1 injection.
Bindarit protects mice against trinitrobenzene sulfonic acid-induced colitis.
Bindarit reduces tumor growth and macrophage recruitment, rendering necrotic tumor masses in melanoma-bearing mice.

Physicochemical Properties

M.Wt 324.38
Formula C19H20N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid

References

1. Gazzaniga S, et al. J Invest Dermatol. 2007 Aug;127(8):2031-41.

2. Grassia G, et al. Cardiovasc Res. 2009 Dec 1;84(3):485-93.

3. Bhatia M, et al. Inflamm Res. 2008 Oct;57(10):464-71.

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