Chemical Structure : Bio-AMS
CAS No.:
1393881-52-1
Bio-AMS
Catalog No.: PC-23818Not For Human Use, Lab Use Only.
Bio-AMS is a potent bacterial biotin protein ligase (BPL) inhibitor, possesses selective activity against Mycobacterium tuberculosis (Mtb) and inhibits fatty acid and lipid biosynthesis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Bio-AMS is a potent bacterial biotin protein ligase (BPL) inhibitor, possesses selective activity against Mycobacterium tuberculosis (Mtb) and inhibits fatty acid and lipid biosynthesis.
In biotin-free medium, the BPL inhibitor Bio-AMS was bactericidal at a concentration of 5 µM.
Bio-AMS inhibited growth of Mtb in a concentration-dependent manner in Mtb-infected mouse macrophages in vitro.
Bio-AMS enhances the activity of rifampicin and ethambutol in vitro. can prevent growth of both drug-sensitive and drug-resistant Mtb in vitro.
Physicochemical Properties
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M.Wt
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571.63
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Formula
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C20H29N9O7S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(N-(((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)sulfamoyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
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References
1. Tiwari D, et al. Sci Transl Med. 2018 Apr 25;10(438):eaal1803.
2. Bockman MR, et al. ACS Infect Dis. 2018 Jul 13;4(7):1102-1113.
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