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Chemical Structure : Birinapant
CAS No.: 1260251-31-7
Catalog No.: PC-21402Not For Human Use, Lab Use Only.
Birinapant (TL32711) is a bivalent, selective small molecule SMAC mimetic, binds with high affinity to multiple members of the IAP family with Kd of 45 nM and <1 nM for XIAP and cIAP1 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $208 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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Birinapant (TL32711) is a bivalent, selective small molecule SMAC mimetic, binds with high affinity to multiple members of the IAP family with Kd of 45 nM and <1 nM for XIAP and cIAP1 respectively.
Birinapant (TL32711) binds to the BIR3 domains of cIAP1, cIAP2, XIAP, and the BIR domain of ML-IAP in vitro.
v specifically targets cIAP1 and cIAP2 for degradation, resulting in a switch in TNFR signaling; activation of TNFR upon binding of TNF-α in the presence of cIAP1 and cIAP2 leads to NF-κB activation and increased cell proliferation.
Birinapant (TL32711) in combination with TNF-α elicites anti-melanoma effect in a parental and BRAF inhibitor resistant cell line.
Birinapant (TL32711) preferentially targets the TRAF2-associated cIAP1 and cIAP2 with subsequent inhibition of TNF-induced NF-κB activation.
Birinapant (TL32711) inhibits umor growth in multiple primary patient-derived xenotransplant models.
| M.Wt | 806.96 | |
| Formula | C42H56F2N8O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
FC1=CC=C(C(C[C@H]2N(C[C@H](C2)O)C([C@H](CC)NC([C@H](C)NC)=O)=O)=C(C3=C(C4=CC=C(F)C=C4N3)C[C@H]5N(C[C@H](C5)O)C([C@H](CC)NC([C@H](C)NC)=O)=O)N6)C6=C1 |
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1. Benetatos CA, et al. Mol Cancer Ther. 2014 Apr;13(4):867-79.
2. Krepler C, et al. Clin Cancer Res. 2013 Apr 1;19(7):1784-94.
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