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Chemical Structure : Bivalirudin
CAS No.: 128270-60-0
Catalog No.: PC-73174Not For Human Use, Lab Use Only.
Bivalirudin (Bivalitroban) is a potent, selective inhibitor of α- and ζ-thrombin (Ki= 2.56 and 1.84 nM, respectively), exhibits high fibrinogen-clotting activities.
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|---|---|---|---|
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| 100 mg | $358 | In stock | |
| 500 mg | $758 | In stock | |
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Bivalirudin (Bivalitroban) is a potent, selective inhibitor of α- and ζ-thrombin (Ki= 2.56 and 1.84 nM, respectively), exhibits high fibrinogen-clotting activities.
Bivalirudin displays >1,000-fold selecivity for α- and ζ-thrombin over trypsin and γ-thrombin.
Bivalirudin inhibits α-thrombin-stimulated activation of the clotting factors Factor X, Factor V, and prothrombin in contact-activated plasma at 0.1 uM.
Bivalirudin (0.5-1.5 mg/kg, i.v.) reduces platelet deposition in a rat carotid endarterectomy model in a dose-dependent manner.
| M.Wt | 2180.3 | |
| Formula | C98H138N24O33 | |
| Appearance | Solid | |
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1. Witting, J.I., et al. Biochem J. 283(Pt 3), 737-743 (1992).
2. Ofosu, F.A., et al. Biochem J. 283(Pt 3), 893-897 (1992).
3. Hamelink, J.K., et al. J. Vasc. Surg. 21(3), 492-498 (1995).
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