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Chemical Structure : Bragsin2
CAS No.: 342795-08-8
Catalog No.: PC-36078Not For Human Use, Lab Use Only.
Bragsin2 (Bragsin 2) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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Bragsin2 (Bragsin 2) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM).
Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer to render BRAG2 unable to activate lipidated Arf, requires membranes for specific inhibition of BRAG2; affects tumorsphere formation in breast cancer cell lines.
Bragsin1 and Bragsin 2 are novel compounds that function by altering protein-membrane interactions without disruption.
| M.Wt | 289.166 | |
| Formula | C11H6F3NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-methoxy-5-nitro-2-(trifluoromethyl)-4H-chromen-4-one |
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1. Nawrotek A, et al. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.
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