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Chemical Structure : Brigatinib
CAS No.: 1197953-54-0
Catalog No.: PC-43260Not For Human Use, Lab Use Only.
Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib.
Brigatinib (AP-26113, AP26113) shows high activity against both sensitive and resistant H3122 cells, decreasing cell growth, suppressing ALK phosphorylation, and inducing apoptosis.
Brigatinib (AP-26113, AP26113) is also active in Ba/F3 cells expressing either native or mutant EML4-ALK with IC50 of 10 and 24 nM, respectively.
Brigatinib (AP-26113, AP26113) demonstrates promising activity in crizotinib resistant.
| M.Wt | 584.0924 | |
| Formula | C29H39ClN7O2P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in Ethanol |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]- |
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1. Katayama R, et al. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40.
2. Ceccon M, et al. Mol Cancer Res. 2013 Feb;11(2):122-32.
3. Ceccon M, et al. Mol Cancer Res. 2015 Apr;13(4):775-83.
4. Fontana D, et al. Cancer Med. 2015 Jul;4(7):953-65.
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