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Chemical Structure : Brusatol
CAS No.: 14907-98-3
Catalog No.: PC-35259Not For Human Use, Lab Use Only.
Brusatol (NSC 172924, (+)-Brusatol) is a quassinoid extracted from Brucea Esters, can inhibit HIF-1 signaling pathway, also is a potent Nrf2 inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Brusatol (NSC 172924, (+)-Brusatol) is a quassinoid extracted from Brucea Esters, can inhibit HIF-1 signaling pathway, also is a potent Nrf2 inhibitor.
Brusatol selectively reduces the protein level of Nrf2 through enhanced ubiquitination and degradation of Nrf2.
Brusatol enhances the efficacy of cisplatin, induces apoptosis, reduces cell proliferation, and inhibits tumor growth more substantially when compared with cisplatin treatment alone in A549 xenografts.
Brusatol down-regulates HIF-1α protein levels under hypoxia or CoCl2-induced mimic hypoxia in HCT116 cells without causing significant cytotoxicity.
| M.Wt | 520.531 | |
| Formula | C26H32O11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxo-, methyl ester, (11b,12a,15b)- (9CI) |
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1. Evans JP, et al. Oncotarget. 2018 Jun 5;9(43):27104-27116.
2. Ren D, et al. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1433-8.
3. Xiang Y, et al. Biochem Biophys Res Commun. 2017 Jun 10;487(4):820-826.
4. Lu Y, et al. Sci Rep. 2016 Dec 16;6:39123.
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