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Bulevirtide

Chemical Structure : Bulevirtide

CAS No.: 2012558-47-1

Bulevirtide (Myrcludex B)

Catalog No.: PC-20252Not For Human Use, Lab Use Only.

Bulevirtide (Myrcludex B, MyrB) is an acylated peptide derived from the large HBV envelope protein, inhibits virus entry and infection.

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Biological Activity

Bulevirtide (Myrcludex B, MyrB) is an acylated peptide derived from the large HBV envelope protein, inhibits virus entry and infection.
Bulevirtide (Myrcludex B) prevents HBV or woolly monkey hepatitis B virus infection in vivo, using immunodeficient urokinase-type plasminogen activator (uPA) mice repopulated with primary human or Tupaia belangeri hepatocytes.

Physicochemical Properties

M.Wt 5398.86
Formula C234H329N65O71
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

{Myr}-Gly-Thr-Asn-Leu-Ser-Val-Pro-Asn-Pro-Leu-Gly-Phe-Phe-Pro-Asp-His-Gln-Leu-Asp-Pro-Ala-Phe-Gly-Ala-Asn-Ser-Asn-Asn-Pro-Asp-Trp-Asp-Phe-Asn-Pro-Asn-Lys-Asp-His-Trp-Pro-Glu-Ala-Asn-Lys-Val-Gly-NH2

References

1. Wisskirchen K, et al. J Clin Invest. 2019 Apr 30;129(7):2932-2945.

2. Petersen J, et al. Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat Biotechnol. 2008;26(3):335–341.

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