Catalog No.: PC-25860Not For Human Use, Lab Use Only.
Butyzamide is a potent, specific non-peptidyl activator /agonist of Thrombopoietin (TPO) receptor Mpl, promotes the proliferation of Ba/F3-hMpl cells with EC50 of 10 nM.
Butyzamide is a potent, specific non-peptidyl activator /agonist of Thrombopoietin (TPO) receptor Mpl, promotes the proliferation of Ba/F3-hMpl cells with EC50 of 10 nM. Butyzamide does not promotes the proliferation of parental Ba/F3 cells that does not express human Mpl. Butyzamide shows species specificity for human but not murine Mpl, Butyzamide does not stimulate other cytokine receptors of EPO, G-CSF, GM-CSF and IL-3. Butyzamide induces phosphorylated JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells. Butyzamide induced colony-forming unit-megakaryocyte and polyploid megakaryocytes from human CD34+ hematopoietic progenitor cells. Butyzamide (3 uM) increased polyploid megakaryocytes in a similar manner to 1 nM rhTPO. Butyzamide (10 or 50 mg/kg once daily for 20 daysincreased human platelets in FL-CD34+-transplanted NOG mice.
