C301-9181

Chemical Structure : C301-9181

Catalog No.: PC-28679Not For Human Use, Lab Use Only.

C301-9181 is a small-molecule inhibitor of aminopeptidase-like 1 (NPEPL1) that directly binds NPEPL1 with micromolar affinity (KD=2.77 uM), suppresses NPEPL1 expression and aminopeptidase activity, and exhibits anti-HCC efficacy in vitro and in vivo.

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Biological Activity

Physicochemical Properties

M.Wt	375.45
Formula	C20H17N5OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((5,6-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)thio)phenyl)benzamide

References

1. Yu Qin, et al. Targeting SRF-activated aminopeptidase NPEPL1 with a novel small-molecule inhibitor offers a potential therapeutic strategy for hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research

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C301-9181

Biological Activity

Physicochemical Properties

References

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