Chemical Structure : C4-180
CAS No.:
C4-180
Catalog No.: PC-25585Not For Human Use, Lab Use Only.
C4-180 is a potent, specific small molecule pan-RALGEF (Ras-like small GTPases exchange factors) inhibitor, specifically inhbits RAL but not MAPK/AKT signaling, impairs the interaction of RALGEFs with RAS.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
C4-180 is a potent, specific small molecule pan-RALGEF (Ras-like small GTPases exchange factors) inhibitor, specifically inhbits RAL but not MAPK/AKT signaling, impairs the interaction of RALGEFs with RAS.
C4-180 directly binds RALGDS with KD value of 2.55 uM in MST assays.
C4-180 acts on both RALGDS and RGL2.
C4-180 inhibits soft agar growth of RAS driven tumor cells with IC50 of <500 nM.
C4-180 specifically suppress RAS signaling through the RAL pathway.
C4-180 (40mg/kg) inhibits tumor formation and metastasis in pancreatic cancer models, with no detectable toxicity.
Physicochemical Properties
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M.Wt
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436.55
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Formula
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C24H25FN4OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(((3-fluorobenzyl)amino)methyl)-N-(3-methoxybenzyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine
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References
1. Donninger H, et al. J Biol Chem. 2025 Oct 8:110809.
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