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Chemical Structure : CA224
Catalog No.: PC-60479Not For Human Use, Lab Use Only.
A non-planar analogue of fascaplysin that selectively inhibits CDK4/cyclin D1 with IC50 of 5.5 uM.
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A non-planar analogue of fascaplysin that selectively inhibits CDK4/cyclin D1 with IC50 of 5.5 uM; does not inhibits CDK2, blocks the growth of cancer cells at G0/G1 phase of the cell cycle, also blocks the cell cycle at G2/M phase; also acts as an enhancer of depolymerization for taxol-stabilized tubulin.
| M.Wt | 354.453 | |
| Formula | C24H22N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mahale S, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4272-8.
2. Mahale S, et al. J Med Chem. 2014 Nov 26;57(22):9658-72.
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