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Chemical Structure : CAD204520
Catalog No.: PC-38269Not For Human Use, Lab Use Only.
CAD204520 (CAD 204520) is a potent, specific, orally available inhibitor of SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) with IC50 of 0.34 uM.
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CAD204520 (CAD 204520) is a potent, specific, orally available inhibitor of SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) with IC50 of 0.34 uM.
CAD204520 preferentially targets mutated over wild-type NOTCH1 proteins in T-All and MCL.
CAD204520 preferentially inhibited the Ca2+-ATPase by reducing SERCA's ATP hydrolysis activity with an IC50=0.34 uM as compared to the Na+/K+-ATPase (IC50, 8.30 uM) and the H+-ATPase.
CAD204520 modulates Notch1 signaling, and preferentially inhibits NOTCH1 mutated cancers.
CAD204520 suppresses NOTCH1-mutated leukemic cells in a T-ALL xenografted model without causing cardiac toxicity.
| M.Wt | 512.439 | |
| Formula | C23H34Cl2F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marchesini M, et al. Cell Chem Biol. 2020 Jun 18;27(6):678-697.e13.
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