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Chemical Structure : CB-64D
Catalog No.: PC-60748Not For Human Use, Lab Use Only.
CB-64D is a potent, selective sigma-2 receptor agonist with Ki of 16.5 nM, 200-fold selectivity over sigma 1 (Ki=3063 nM).
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CB-64D is a potent, selective sigma-2 receptor agonist with Ki of 16.5 nM, 200-fold selectivity over sigma 1 (Ki=3063 nM).
CB-64D significantly induces the calcium signal and cell death in SK-N-SH cells, produces dose-dependent cytotoxicity.
CB-64D induces apoptosis in MCF-7 and T47D breast tumor cell lines.
| M.Wt | 333.431 | |
| Formula | C22H23NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nicholson H, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12.
2. Bowen WD, et al. Eur J Pharmacol. 1995 May 24;278(3):257-60.
3. Vilner BJ, et al. J Pharmacol Exp Ther. 2000 Mar;292(3):900-11.
4. Crawford KW, et al. Cancer Res. 2002 Jan 1;62(1):313-22.
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