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Chemical Structure : CBL0137
CAS No.: 1197996-80-7
Catalog No.: PC-60543Not For Human Use, Lab Use Only.
CBL0137 (Curaxin CBL0137) is a histone chaperone FACT (facilitates chromatin transcription) and MYC signal inhibitor that markedly reduced tumor initiation and progression in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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CBL0137 (Curaxin CBL0137) is a histone chaperone FACT (facilitates chromatin transcription) and MYC signal inhibitor that markedly reduced tumor initiation and progression in vivo.
CBL0137 simultaneously activates p53 and inhibits NF-κB without causing detectable genotoxicity, causes phosphorylation of p53 Ser(392) by CK2 and inhibition of NF-κB-dependent transcription in neuroblastoma cells; .
CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.
| M.Wt | 336.435 | |
| Formula | C21H24N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,1'-(9-(2-(isopropylamino)ethyl)-9H-carbazole-3,6-diyl)bis(ethan-1-one) |
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1. Carter DR, et al. Sci Transl Med. 2015 Nov 4;7(312):312ra176.
2. Gasparian AV, et al. Sci Transl Med. 2011 Aug 10;3(95):95ra74.
3. Burkhart C, et al. Oncotarget. 2014 Nov 30;5(22):11038-53.
4. Barone TA, et al. Neuro Oncol. 2017 Feb 1;19(2):186-196.
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