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Chemical Structure : CBR417
Catalog No.: PC-72980Not For Human Use, Lab Use Only.
CBR417 (CBR-417) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=21 nM, IC90=1640 nM).
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CBR417 (CBR-417) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=21 nM, IC90=1640 nM).
CBR417 demonstrates potent antiwolbachial activity was confirmed in L. sigmodontis, Brugia malayi, and Onchocerca ochengi in vivo preclinical models of filarial disease.
CBR417 demonstrates in vitro selectivity against Loa loa (a safety concern in endemic areas).
| M.Wt | 444.384 | |
| Formula | C17H13F5N6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Malina A Bakowski, et al. Sci Transl Med. 2019 May 8;11(491):eaav3523.
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