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Chemical Structure : CBR490
Catalog No.: PC-72981Not For Human Use, Lab Use Only.
CBR490 (CBR-490) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=33 nM, IC90=283 nM).
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CBR490 (CBR-490) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=33 nM, IC90=283 nM).
CBR490 demonstrates potent antiwolbachial activity was confirmed in L. sigmodontis, Brugia malayi, and Onchocerca ochengi in vivo preclinical models of filarial disease.
CBR490 demonbstrated in vitro selectivity against Loa loa (a safety concern in endemic areas).
| M.Wt | 438.42 | |
| Formula | C20H15F5N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Malina A Bakowski, et al. Sci Transl Med. 2019 May 8;11(491):eaav3523.
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