CBR703 | Bacterial RNA polymerase | Probechem Biochemicals

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Chemical Structure : CBR703

CBR703 (C0340703)

Catalog No.: PC-26174Not For Human Use, Lab Use Only.

CBR703 (C0340703) is a specific small molecule bacterial RNA polymerase (RNAP) inhibitor, inhibits catalytic activities of RNAP but not translocation of RNA or DNA, inhibits nucleotide addition.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CBR703 (C0340703) is a specific small molecule bacterial RNA polymerase (RNAP) inhibitor, inhibits catalytic activities of RNAP but not translocation of RNA or DNA, inhibits nucleotide addition.

Physicochemical Properties

M.Wt	280.25
Formula	C14H11F3N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Hydroxy-N′-phenyl-3-(trifluoromethyl)benzenecarboximidamide

References

1. Artsimovitch I, et al. A new class of bacterial RNA polymerase inhibitor affects nucleotide addition. Science. 2003 Oct 24;302(5645):650-4.

2. Villain-Guillot P, et al. Antimicrob Agents Chemother. 2007 Sep;51(9):3117-21.

3. Malinen AM, et al. Nat Commun. 2014 Mar 6;5:3408.

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CBR703 (C0340703)

Biological Activity

Physicochemical Properties

References

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