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Chemical Structure : CC-115 hydrochloride
CAS No.: 1300118-55-1
Catalog No.: PC-45102Not For Human Use, Lab Use Only.
A novel dual inhibitor of mTOR and DNA-PK with IC50 of 21 nM and 13 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $152 | In stock | |
| 50 mg | $520 | In stock | |
| 100 mg | $792 | In stock |
Bulk size, bulk discount!
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A novel dual inhibitor of mTOR and DNA-PK with IC50 of 21 nM and 13 nM, respectively; blocks both mTORC1(pS6) and mTORC2(pAktS473) signaling in PC-3 cancer cells, in vitro and in vivo; exhibits dose-dependent efficacy in tumor xenograft models.
Blood Cancer
Phase 1 Clinical
| M.Wt | 372.8122 | |
| Formula | C16H17ClN8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-, hydrochloride (1:x) |
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1. Mortensen DS, et al. J Med Chem. 2015 Jul 23;58(14):5599-608.
2. Thijssen R, et al. Blood. 2016 Jul 28;128(4):574-83.
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